Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- General Anesthesia
- Type
- Interventional
- Phase
- Phase 4
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Other
Participation Requirements
- Age
- Between 18 years and 80 years
- Gender
- Both males and females
Description
All patients receive standardized anesthesia care for pancreaticoduodenectomy according to the existing departmental protocol for these interventions. All patients receive individualized goal-directed hemodynamic therapy based on the transpulmonary thermodilution technique. At designated times, hemo...
All patients receive standardized anesthesia care for pancreaticoduodenectomy according to the existing departmental protocol for these interventions. All patients receive individualized goal-directed hemodynamic therapy based on the transpulmonary thermodilution technique. At designated times, hemodynamic variables will be recorded. These include : Heart rate (bpm) Central venous pressure (mmHg) Systolic arterial pressure (mmHg) Diastolic arterial pressure (mmHg) Mean arterial pressure (mmHg) Cardiac index (L/min/m2) Pulse pressure variation (PPV) Stroke volume variation (SVV) Measurements of hepatic flow and pressure will be performed by the surgeon : Hepatic flow : in the hepatic artery (arterial HBF) and portal vein (portal HBF). Pressure measurements : in portal vein (PPorta) and caval vein (PCava) Measurements will be done : without inotropic support with infusion of dobutamine 2mcg/kg/min with infusion of dobutamine 5mcg/kg/min
Tracking Information
- NCT #
- NCT04893655
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jurgen Van Limmen, MD UZ Ghent
Get Well Soon