Collateral Circulation in Acute Ischemic Stroke With Large Vessel Occlusion
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Collateral Circulation, Any Site
- Stroke Acute
- Stroke Ischemic
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Introduction. In patients with an acute ischemic stroke due to a large-vessel intracranial occlusion (LVO), the status of the colateral circulation (CC) is related to clinical outcome and to the success of mechanical thrombectomy. However, CC is highly variable from patient to patient. Methods. An o...
Introduction. In patients with an acute ischemic stroke due to a large-vessel intracranial occlusion (LVO), the status of the colateral circulation (CC) is related to clinical outcome and to the success of mechanical thrombectomy. However, CC is highly variable from patient to patient. Methods. An observational, prospective, multicenter study of 700 consecutive patients with acute ischemic stroke and a LVO. Factors to be evaluated: 1) Modifiable: Vascular risk factors, blood analysis, prior medications, vital constants (with emphasis on continuous blood pressure monitoring), head position, metrics (time to admission, Computed tomography (CT), groin puncture, end of procedure), 2) Non-modifiable: age, sex, completeness of Circle of Willis, etiology, type of mechanical thrombectomy, plasma biomarkers, genetic/epigenetic factors (a discovery phase with GWAs study and a replication phase). CC grade will be assessed by the ASITN/SIR collateral score from CT-angiography (CTA) and the Digital substraction angiography (DSA, when performed). Statistics: bivariate analyses and a logistic regression to predict CC grade (poor versus good) and CC persistence comparing CTA with DSA (4 possibilities: poor-poor, poor-good, good-poor, good-good). Expected results. Our study may find markers of the CC status, facilitate the design of clinical trials to improve CC grade, may find new therapeutic targets and new treatments to enhance the beneficial effects of mechanical thrombectomy.
Tracking Information
- NCT #
- NCT04882657
- Collaborators
- Instituto de Salud Carlos III
- Complejo Hospitalario Universitario de Albacete
- Hospital de Cruces
- Hospital Clínico Universitario de Valladolid
- Hospitales Universitarios Virgen del Rocío
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
- Hospital Universitario La Paz
- Hospital del Mar
- Hospital Arnau de Vilanova
- Complexo Hospitalario Universitario de A Coruña
- Red de Enfermedades Vasculares Cerebrales INVICTUS PLUS (Rd1600190024)
- Investigators
- Not Provided