Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Acute Coronary Syndrome
- Atheroma; Heart
- Atherosclerosis
- Atherosclerosis Coronary Artery With Angina Pectoris
- Atherosclerosis, Coronary
- Emotional Stress
- Hematopoiesis
- Inflammation
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 20 years and 75 years
- Gender
- Both males and females
Description
Thirty two patients with multivessel coronary artery disease (including both stable angina and acute coronary syndrome), who have at least one severe obstructive lesion (>70% diameter stenosis) that is considered suitable for percutaneous coronary intervention (PCI), will be included in the study. S...
Thirty two patients with multivessel coronary artery disease (including both stable angina and acute coronary syndrome), who have at least one severe obstructive lesion (>70% diameter stenosis) that is considered suitable for percutaneous coronary intervention (PCI), will be included in the study. Structural/biochemical characteristics of coronary culprit plaque (with or without mild to moderate stenotic non-culprit plaque) will be assessed comprehensively using OCT-FLIM dual modal intravascular imaging. After coronary revascularization with PCI, subjects will undergo serial 18F-FDG-PET/CT molecular imaging at baseline admission and 6-month follow-up to measure PET signal activities at target tissues including amygdala, carotid artery, aorta, bone marrow, and spleen. Correlation between OCT-FLIM parameters and baseline PET signals will be assessed to provide insight into the mechanistic linkage between multi-system metabolic activities and coronary plaque instability. Serial PET/CT imaging after 6 month will enable estimation of natural course of multi-system PET signal activities according to different levels of coronary plaque instability.
Tracking Information
- NCT #
- NCT04853511
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jin Won Kim, MD, PhD Korea University Guro Hospital Study Director: Dong Oh Kang, MD, PhD Korea University Guro Hospital Study Director: Sun Won Kim, MD, PhD Korea University Study Director: Hongki Yoo, PhD Korea Advanced Institute of Science and Technology