(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Gingivitis
- Healthy
- Periodontitis
- Type
- Observational
- Design
- Observational Model: OtherTime Perspective: Cross-Sectional
Participation Requirements
- Age
- Between 18 years and 70 years
- Gender
- Both males and females
Description
Periodontitis is a destructive chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. Inflammasomes are cytosolic multiprotein complex involved in the initiatio...
Periodontitis is a destructive chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. Inflammasomes are cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Interleukine -1? ( IL-1? ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Interleukine-10 (IL-10) has been reported to decrease periodontal disease progression rate. Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies. Both NLRC4 and NLRP3 inflammasomes have been shown to play an important role in the induction of interleukin-1? secretion. Periodontitis is induced by a complex microbial biofilm containing multiple Gram-positive and Gram-negative bacteria (including flagellate microorganisms) capable of activating a large number of NLRs. It has been said that proinflammatory cytokines released in the microenvironment of periodontitis can increase the expression of NLRC4 inflammasome genes. Evidence on the role of inflammasomes in periodontal disease is still very poor. The aim of this study is to compare the NLRC4, IL-1? and IL-10 levels of healthy and periodontitis individuals.
Tracking Information
- NCT #
- NCT04850768
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Ay?e Toraman, Dr Saglik Bilimleri Universitesi Study Chair: Ebru Sa?lam, Dr Saglik Bilimleri Universitesi Study Chair: Serhat Köseo?lu, assoc prof Saglik Bilimleri Universitesi Study Chair: Mehmet Sa?lam, assoc prof Izmir Katip Celebi University Study Chair: Levent Savran, PhD Izmir Katip Celebi University