Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Adults
- Anesthesia
- Postoperative Pain
- Type
- Interventional
- Phase
- Phase 4
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Experimental group : Control group=2:1Masking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Patients often suffer acute pain after operation ?which may affect the recovery. Opioid such as morphine is the most commonly analgesic drugs, but opioid has many obviously adverse reactions ,for example respiratory depression,circulation inhibition,tolerance, addiction, nausea, vomiting, pruritus, ...
Patients often suffer acute pain after operation ?which may affect the recovery. Opioid such as morphine is the most commonly analgesic drugs, but opioid has many obviously adverse reactions ,for example respiratory depression,circulation inhibition,tolerance, addiction, nausea, vomiting, pruritus, etc. S (+) - ketamine has been described to decrease acute pain and opioid consumption,but it needs to confirm for chinese patients undergoing surgery. Objective:Evaluate the efficacy and safety of S (+) - ketamine on acute perioperative pain for chinese adult patients,and look for the best dosage, mode of administration, timing, and compatibility ,as well explore the effect of S (+) - ketamine on postoperative delirium,anxiety ,depression and cognitive dysfunction.
Tracking Information
- NCT #
- NCT04837170
- Collaborators
- Jiangsu Provincial People's Hospital
- Beijing Hospital
- The Affiliated Hospital of Qingdao University
- Renmin Hospital of Wuhan University
- First Affiliated Hospital Xi'an Jiaotong University
- First Affiliated Hospital, Sun Yat-Sen University
- Shengjing Hospital
- Southern Medical University, China
- Investigators
- Study Chair: Weidong Mi, MD Chinese PLA General Hospital