Reversing Glucose and Lipid-mediated Vascular Dysfunction
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Blood Pressure
- Hypertension
- Type
- Interventional
- Phase
- Early Phase 1
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Comparisons of outcome variables will be made using a mixed model ANOVA.Masking: Triple (Participant, Care Provider, Investigator)Masking Description: Randomized, double-blinded, parallel-design approach study.Primary Purpose: Other
Participation Requirements
- Age
- Between 18 years and 79 years
- Gender
- Both males and females
Description
Hypertension, obesity, and insulin resistance are associated with elevated muscle sympathetic nerve activity (MSNA), which is important for blood pressure regulation. The measurement of MSNA is safely performed in humans using the microneurographic technique that involves recording sympathetic nerve...
Hypertension, obesity, and insulin resistance are associated with elevated muscle sympathetic nerve activity (MSNA), which is important for blood pressure regulation. The measurement of MSNA is safely performed in humans using the microneurographic technique that involves recording sympathetic nerve activity projecting to skeletal muscle using a small microelectrode at the peroneal nerve near the knee. The health of your blood vessels will be tested in this study, in addition to the activity of the nerves that control the blood vessels. The function of the nerves and blood vessels can be diminished by high blood glucose and lipids, and we will test the ability of a well-known antioxidant, ascorbic acid (vitamin C), to restore the function of the nerves and blood vessels.
Tracking Information
- NCT #
- NCT04832009
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Seth W. W Holwerda, PhD University of Kansas Medical Center
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