Early Enteral Nutrition for Patients Undergoing Donor Stem Cell Transplantation for Hematological Malignancies

OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive enteral nutrition via nasoenteric feeding tube starting on day 1 until hospital discharge. ARM II: Patients receive standard of care nutritional support.

Feasibility of Implementing Early Enteral Nutrition for Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Hematological Malignancies

This clinical trial examines early enteral nutrition for patients undergoing donor stem cell transplantation for hematological malignancies. Patients undergoing donor stem cell transplantation often develop oral and gastrointestinal damage from chemotherapy, radiotherapy, or graft-versus-host disease that makes oral intake inadequate for meeting nutritional needs, especially during the catabolic period of recovery. Parenteral (intravenous) nutrition often requires a large fluid load, has been associated with increased risk of infection, can be associated with metabolic complications such as hyperglycemia and hypertriglyceridemia, is linked to elevated liver function tests, and may deprive the gastrointestinal mucosa of factors thought to promote mucosal integrity and healing. Enteral nutrition via a nasoenteric feeding tube is an alternate method of nutrition support. Giving early enteral nutrition may be more tolerable for patients undergoing a stem cell transplant.

Early Enteral Nutrition for Patients Undergoing Donor Stem Cell Transplantation for Hematological Malignancies

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