Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Critically Ill
- Sleep Deprivation
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: None (Open Label)Primary Purpose: Prevention
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Up to 61% of critically ill patients have sleep deprivation in ICU. Sleep deprivation can cause delirium and lead to prolonged ICU length of stay and mechanical ventilator days. However, pharmacologic interventions to improve sleep quality and prevent sleep deprivation are poorly tested for efficacy...
Up to 61% of critically ill patients have sleep deprivation in ICU. Sleep deprivation can cause delirium and lead to prolonged ICU length of stay and mechanical ventilator days. However, pharmacologic interventions to improve sleep quality and prevent sleep deprivation are poorly tested for efficacy and safety in ICU patients. There were reports of gabapentin increasing slow-wave sleep in healthy populations and insomnia patients with insignificant adverse events. Therefore, gabapentin might increase slow-wave sleep resulting in improving clinical outcomes in adult critically ill patients. The objectives of the study were to evaluate the efficacy, especially on slow-wave sleep, and safety of gabapentin in adult critically ill patients admitted to ICUs at Ramathibodi Hospital, a university hospital, Thailand.
Tracking Information
- NCT #
- NCT04818450
- Collaborators
- Not Provided
- Investigators
- Study Director: Yuda Sutherasan, MD Ramathibodi hospital, Mahidol university Principal Investigator: Kanyarat Susantitapong, B.Sc.(Pharm) Mahidol University Study Director: Pitchaya Dilokpattanamongkol, BCPS, BCCCP, BCP Mahidol University Study Chair: Chuthamanee Suthisisang, Ph.D. Mahidol University Study Chair: Viratch Tangsujaritvijit, Ph.D. Piyavate Hospital
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