Azacitidine in Combination With Venetoclax Treatment for MRD Positive Post Allo-HSCT AML/MDS Patients
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Hematologic Malignancy
- Stem Cell Transplant Complications
- Type
- Interventional
- Phase
- Phase 2
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Prevention
Participation Requirements
- Age
- Between 18 years and 65 years
- Gender
- Both males and females
Description
The technology of Allogeneic Hematopoietic stem cell transplantation (allo-HSCT) has been continuously improved, relpase is still the leading cause of death after allo-HSCT. Monitoring of micro residual disease (MRD) after allogeneic HSCT provides a risk stratification of relpase risk in patients af...
The technology of Allogeneic Hematopoietic stem cell transplantation (allo-HSCT) has been continuously improved, relpase is still the leading cause of death after allo-HSCT. Monitoring of micro residual disease (MRD) after allogeneic HSCT provides a risk stratification of relpase risk in patients after transplantation.There is an urgent need to find an effective intervention plan for patients with MRD positive after transplantation, in order to reduce the risk of relapse after transplantation and improve long-term survival.The combination of demethylated drugs with venetoclax has shown promising results in clinical trials in AML patients who cannot tolerate induction chemotherapy.In patients with MRD-positive patients after AML/MDS allo-HSCT, azacytidine combined with venetoclax may be effective in eliminating small residual diseases, reducing the risk of relapse, and ultimately improving long-term survival.The primary purpose of this study was to explore an effective protocol to reduce the risk of relapse in patients with MRD positive after allo-HSCT for AML/MDS.
Tracking Information
- NCT #
- NCT04809181
- Collaborators
- Sir Run Run Shaw Hospital
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Zhejiang Provincial People's Hospital
- The First Affiliated Hospital of Zhejiang Chinese Medical University
- First Affiliated Hospital of Wenzhou Medical University
- Ningbo No. 1 Hospital
- Yinzhou Hospital Affiliated to Medical School of Ningbo University
- Jinhua Central Hospital
- Taizhou Hospital
- Union hospital of Fujian Medical University
- Xiangya Hospital of Central South University
- Investigators
- Principal Investigator: Yi Luo, M.D. First Affilaated Hospital of Medical School of Zhejiang University