Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

Summary

Participation Requirements

Description

In Group A, the investigators will evaluate the performance of healthy older participants (N = 500, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. The goal is to characterize changes in performance to aging and task experience in a gr...

In Group A, the investigators will evaluate the performance of healthy older participants (N = 500, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. The goal is to characterize changes in performance to aging and task experience in a group of older subjects. Subjects will also undergo APOE genetic testing with saliva samples. In Group B, the investigators will compare the performance of normal participants (N = 100, age range 18 to 89) on computerized and manually administered cognitive tasks. In Group C, the investigators will gather normative data from younger participants (N = 400, ages 18 to 59) for three days at enrollment. A subset of these subjects (N=150) will undergo longitudinal testing at 6-month intervals for three years thereafter. In Group D, the investigators will examine the performance of participants (N=1000, ages 18 to 89) on a 30-min computerized cognitive screening test.

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