Saxon SARS-CoV-2 Infection and Vaccination Study in Dialysis Patients, Solid Organ Recipients and Staff
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Active Immunization
- Immune Response
- Immunosuppression
- SARS CoV-2 Infection
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 100 years
- Gender
- Both males and females
Description
Formation of two separate cohorts of approximately 1000 study subjects each from the three categories (dialysis patients, solid organ transplant recipients and medical staff) of participants vaccinated using either Biontech or Moderna vaccine (Biontech cohort and Moderna cohort, approximately 2000 s...
Formation of two separate cohorts of approximately 1000 study subjects each from the three categories (dialysis patients, solid organ transplant recipients and medical staff) of participants vaccinated using either Biontech or Moderna vaccine (Biontech cohort and Moderna cohort, approximately 2000 subjects total). Study time points: Before administration of the 1st SARS-CoV-2 vaccine dose, before the 2nd vaccine dose, and 8 weeks and 6, 9, 12, and 18 months after administration of the 1st vaccine dose and after suspected or proven SARS-CoV-2 infection. At all time points, a questionnaire or eCRF will be completed with questions about the dialysis center and the clinical course of the patients. Humoral immune response will be determined in all study participants. Formation of a study subgroup of up to 300 subjects in each cohort (Biontech or Moderna cohort) for detailed evaluation of the cellular immune response (max. 600 subjects in total). In case of non-sustained immunity > 6 months as well as the occurrence of a 3rd SARS-CoV-2 infection wave in autumn 2021, this will be investigated analogously to the current wave.
Tracking Information
- NCT #
- NCT04799808
- Collaborators
- Universitätsklinikum Leipzig
- Klinikum St. Georg gGmbH
- Charite University, Berlin, Germany
- DRK-Blutspendedienst Nord-Ost gemeinnützige GmbH / Dresden
- DRK-Blutspendedienst Nord-Ost gemeinnützige GmbH / Institut Plauen
- Investigators
- Study Director: Christian Hugo, Prof. Univercity Hospital Carl Gustav Carus