Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data

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Through high-throughput sequencing technologies such as? genome sequencing, transcriptome sequencing and single-cell sequencing, Proteomics?Metabonomics and Metagenomics? the similarities and differences of the glioma immune microenvironment within and between individuals were revealed from the mult...

Through high-throughput sequencing technologies such as? genome sequencing, transcriptome sequencing and single-cell sequencing, Proteomics?Metabonomics and Metagenomics? the similarities and differences of the glioma immune microenvironment within and between individuals were revealed from the multi-dimensional and big data level, and the immune molecular typing of glioma was established. Establish and verify that the neoantigen polypeptides predicted by AI algorithm after analyzing multi-omics data (genome, transcriptome, etc.) have good killing effect on individual tumor cells. To establish an intelligent evaluation model of glioma immunotyping by integrating imaging, pathology, high-throughput sequencing data and other omics information, and to provide a visual tool for monitoring changes in the intratumoral microenvironment of glioma patients, with the expectation of helping timely intervention of immunotherapy in patients with recurrence.

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