Activation of Apoptosis-related Receptors on Alveolar Macrophages
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Chronic Obstructive Pulmonary Disease
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Sequential AssignmentIntervention Model Description: Enrolment will healthy subjects first, followed by subjects with COPDMasking: None (Open Label)Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 40 years and 80 years
- Gender
- Both males and females
Description
In order to assess pathway activation in COPD macrophages, alveolar macrophages will be isolated from BAL of COPD patients and healthy controls. Alveolar macrophages will be co-cultured in vitro with apoptotic cells and treated with compounds. In addition, BAL fluid will be frozen for later testing ...
In order to assess pathway activation in COPD macrophages, alveolar macrophages will be isolated from BAL of COPD patients and healthy controls. Alveolar macrophages will be co-cultured in vitro with apoptotic cells and treated with compounds. In addition, BAL fluid will be frozen for later testing of soluble mediators.
Tracking Information
- NCT #
- NCT04775394
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jens M Hohlfeld, Prof. Dr. Fraunhofer ITEM Hannover, Germany
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