18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Stage IVA Colon Cancer AJCC v8
- Prognostic Stage IV Breast Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
- Stage IV Colon Cancer AJCC v8
- Glioma
- Stage IVB Colon Cancer AJCC v8
- Stage IVB Lung Cancer AJCC v8
- Malignant Brain Neoplasm
- Metastatic Breast Carcinoma
- Metastatic Colon Carcinoma
- Stage IVC Colon Cancer AJCC v8
- Metastatic Kidney Carcinoma
- Metastatic Lung Carcinoma
- Stage IVA Lung Cancer AJCC v8
- Metastatic Malignant Neoplasm in the Brain
- Metastatic Melanoma
- Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Type
- Interventional
- Phase
- Early Phase 1
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Diagnostic
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
PRIMARY OBJECTIVES: I. Assess the correlation between multiparametric magnetic resonance imaging (mpMRI) radiomics and dynamic 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) PET kinetic analysis parameters. II. Explore the different pattern in radiomics mpMRI and FMAU PET kinetic analysis...
PRIMARY OBJECTIVES: I. Assess the correlation between multiparametric magnetic resonance imaging (mpMRI) radiomics and dynamic 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) PET kinetic analysis parameters. II. Explore the different pattern in radiomics mpMRI and FMAU PET kinetic analysis parameters between patients with presence or absence of recurrent tumor. OUTLINE: Patients receive 18F-FMAU intravenously (IV) and undergo a PET/CT scan over 60 minutes. Patients then undergo standard of care mpMRI over approximately 45 minutes. After completion of study intervention, patients are followed up at 24-96 hours after their 18F-FMAU PET/CT scan.
Tracking Information
- NCT #
- NCT04752267
- Collaborators
- National Cancer Institute (NCI)
- Investigators
- Principal Investigator: Hossein Jadvar, MD University of Southern California
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