Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

PRIMARY OBJECTIVE: I. To use a Mendelian randomization study design to determine whether genetically predicted decreased testosterone levels are associated with an increased risk of dementia. SECONDARY OBJECTIVE: I. To examine whether genetically predicted decreased testosterone levels are associated with worse cognitive function and adverse mental health outcomes. OUTLINE: Patients' records from institutional or national biobanks are reviewed.

Evaluation of a Causal Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes: A Mendelian Randomization Analysis

This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.

Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

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