Comparison of Dexmedetomidine and Meperidine for the Prevention of Shivering Following Coronary Artery Bypass Graft

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Shivering is one of the common complications during the perioperative period.The incidence of shivering is high in the patients undergo CABG. Previous studies showed that the incidence could be up to 50?. Shivering could make the patients feel distressed. Moreover, shivering could also cause a signi...

Shivering is one of the common complications during the perioperative period.The incidence of shivering is high in the patients undergo CABG. Previous studies showed that the incidence could be up to 50?. Shivering could make the patients feel distressed. Moreover, shivering could also cause a significant increase in oxygen consumption of patients,which might affect the balance of oxygen supply and demand of the vital organs, such as heart and brain. There are few studies of pharmacological interventions for the prevention of shivering following CABG,and the gold standard prophylactic and therapeutic medicine have not been determined. Previous studies have shown that both dexmedetomidine and meperidine can reduce the incidence of shivering after intrathecal anesthesia and general anesthesia. However, only a few studies have indicated that meperidine can reduce the incidence of shivering in patients undergo off-pump CABG. But meperidine may increase the incidence of postoperative nausea and vomiting. Therefore, the aim of this study is to explore the effectiveness and safety of dexmedetomidine for the prevention of postoperative shivering in the patients undergo elective CABG, and to compare the effectiveness of dexmedetomidine and meperidine on the incidence of shivering in the patients undergo CABG.

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