Endovascular Treatment With Versus Without Intravenous Tenecteplase in Stroke
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Stroke Acute
- Stroke Ischemic
- Type
- Interventional
- Phase
- Phase 2Phase 3
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
The DEVT, SKIP and DIRECT-MT trials showed that endovascular treatment alone is not inferior to intravenous alteplase bridging with endovascular treatment in terms of achieving 90-day functional independence for stroke patients with anterior circulation large vessel occlusion. The EXTEND-IA TNK part...
The DEVT, SKIP and DIRECT-MT trials showed that endovascular treatment alone is not inferior to intravenous alteplase bridging with endovascular treatment in terms of achieving 90-day functional independence for stroke patients with anterior circulation large vessel occlusion. The EXTEND-IA TNK part 1 and part 2 demonstrated that intravenous thrombolysis with tenecteplase is superior to alteplase before endovascular treatment. However, it is unclear whether intravenous tenecteplase bridging with endovascular treatment is superior to endovascular treatment alone. The purpose of this trial is to investigate whether intravenous tenecteplase bridging with endovascular treatment is better than endovascular treatment alone for stroke patients with anterior circulation large vessel occlusion who are thrombolysis-eligible within 4.5 hours of onset.
Tracking Information
- NCT #
- NCT04733742
- Collaborators
- Wuhan No. 1 Hospital (Wenhua Liu)
- The 904th Hospital of PLA (Zhonghua Shi)
- The First Affiliated Hospital of Jilin University (Shouchun Wang)
- Maoming Traditional Chinese Medicine Hospital (Wenguo Huang)
- Investigators
- Principal Investigator: Qingwu Yang, MD Neurology, Xinqiao Hospital of the Army Medical University Principal Investigator: Raul G Nogueira, MD Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University, Atlanta, USA Principal Investigator: Jeffrey L Saver, MD Neurology, University of California, Los Angeles, USA Principal Investigator: Wenjie Zi, MD Neurology, Xinqiao Hospital of the Army Medical University
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