Impact of Fentanyl Analgesia on the Accuracy of HVPG Measurements in Patients With Portal Hypertension
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Liver Cirrhosis
- Pain
- Portal Hypertension
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 75 years
- Gender
- Both males and females
Description
Portal hypertension is a common complication of chronic liver disease and is associated with most clinical consequences of cirrhosis. The most reliable method for assessing portal hypertension is the measurement of the hepatic venous pressure gradient (HVPG). The HVPG is the gold-standard methods fo...
Portal hypertension is a common complication of chronic liver disease and is associated with most clinical consequences of cirrhosis. The most reliable method for assessing portal hypertension is the measurement of the hepatic venous pressure gradient (HVPG). The HVPG is the gold-standard methods for assessing clinically significant portal hypertension and becoming increasingly used clinically. It is useful in the differential diagnosis of portal hypertension and provides a prognostic index in cirrhotic patients. Many patients are painful and reluctant to undergo serial HVPG measurements. But interventionists are reluctant to use analgesics because they always pay more attention to the accuracy of HVPG measurements. May be since it is difficult to monitor HVPG for anesthesiologist during liver surgery, there are very few and controversial studies on the effects of sedation and analgesics on HVPG. M. Susan Mandell et al concluded that desflurane alters HVPG measurements, whereas propofol did not change it (Anesth Analg 2003). However, Enric Reverter et al considered that deep sedation with propofol and remifentanil adds substantial variability and uncertainty to HVPG measurements (Liver International 2013). Although Adam F. et al concluded that low-dose midazolam sedation is an option for patients undergoing serial hepatic venous pressure measurements (Hepatology 1999), the effects of using opioid analgesics alone on hepatic venous pressure measurements have not yet been defined. The objective of this study was to evaluate the effects of fentanyl on the HVPG measurements.
Tracking Information
- NCT #
- NCT04724148
- Collaborators
- LanZhou University
- Lishui hospital of Zhejiang University
- The First Affiliated Hospital with Nanjing Medical University
- The First Affiliated Hospital, Zhejiang University School of Medicine
- Investigators
- Study Chair: Xiaolong Qi, MD LanZhou University Study Chair: Xun Li, MD LanZhou University Study Director: Haijun Zhang, MD LanZhou University Study Director: Lei Li, MD LanZhou University Principal Investigator: Zhongwei Zhao, MD Lishui hospital of Zhejiang University Principal Investigator: Jiansong Ji, PHD Lishui hospital of Zhejiang University Principal Investigator: Chuan guang Wang, Master Lishui hospital of Zhejiang University Principal Investigator: Wei Wu Lishui hospital of Zhejiang University Principal Investigator: Lili Yang Lishui hospital of Zhejiang University Principal Investigator: Yulan Li, MD LanZhou University Principal Investigator: YuJiang Yin LanZhou University Principal Investigator: Wei Yang, master The First Affiliated Hospital with Nanjing Medical University Principal Investigator: Zi Niu Yu, MD The First Affiliated Hospital, Zhejiang University School of Medicine Principal Investigator: Wentao Wu, master The First Affiliated Hospital with Nanjing Medical University Principal Investigator: Xujun Yang, master LanZhou University Principal Investigator: Shuangxi Li LanZhou University Principal Investigator: Fangyu Xu LanZhou University Principal Investigator: Weizhong Zhou, MD The First Affiliated Hospital with Nanjing Medical University
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