Role of Alprazolam in the Management of Acute Coronary Syndrome
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Acute Coronary Syndrome
- Anxiety
- Heart Diseases
- Myocardial Infarction
- ST Elevation Myocardial Infarction
- Type
- Interventional
- Phase
- Phase 1Phase 2
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: This randomized, close label, placebo-controlled study with superiority framework as add-on therapy in ACS patientsMasking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Masking Description: Masking will be done for all participantsPrimary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 60 years
- Gender
- Both males and females
Description
World has studied the increased prevalence of anxiety as a concomitant factor in ACS patients causing detrimental effects on cardiovascular outcomes being anxiety as one of the first responses to chest pain and hospital admission causing tachycardia. This study is designed to achieve the goals of lo...
World has studied the increased prevalence of anxiety as a concomitant factor in ACS patients causing detrimental effects on cardiovascular outcomes being anxiety as one of the first responses to chest pain and hospital admission causing tachycardia. This study is designed to achieve the goals of lowering the heart using the anxiolytic property of alprazolam. This randomized, parallel group, close label, placebo-controlled, event driven, interventional clinical superiority study will be conducted in Cardiology department of Shaikh Zayed Hospital with a sample size of 48 allocating using lottery method in both experimental and control group. Heart Rate at baseline and after 6 hours will be monitored in both groups to establish the fall of heart rate in both patients. Data will be collected by using pre-designed performa and will be entered and analyzed via SAS 9.4. Statistical analysis will be done using T-test and p value <0.05 will be considered significant. Significance of the study is to lower the required dosage of beta-blockers in order to achieve optimum beta-blockade using an anxiolytic while not affecting the blood pressure.
Tracking Information
- NCT #
- NCT04715269
- Collaborators
- Not Provided
- Investigators
- Study Chair: Qazi Abdul Saboor, MBBS Shaikh Zayed Post-Graduate Medical Institute Principal Investigator: Sohaib Ashraf, MBBS Shaikh Zayed Post-Graduate Medical Institute
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