Role of Diet on the Microbiome of the Digestive System
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Colorectal Carcinoma
- Type
- Observational
- Design
- Observational Model: Case-ControlTime Perspective: Cross-Sectional
Participation Requirements
- Age
- Between 50 years and 125 years
- Gender
- Both males and females
Description
PRIMARY OBJECTIVES: I. To evaluate the differences in dietary patterns among individuals reporting to be vegetarian and omnivorous. II. To compare the difference in stool microbiome pattern in the above mentioned two groups of individuals. III. To compare somatic mutations in colorectal epithelial c...
PRIMARY OBJECTIVES: I. To evaluate the differences in dietary patterns among individuals reporting to be vegetarian and omnivorous. II. To compare the difference in stool microbiome pattern in the above mentioned two groups of individuals. III. To compare somatic mutations in colorectal epithelial cells in the above mentioned two groups of individuals. SECONDARY OBJECTIVE: I. To identify and characterize an association between diet, the microbiome and its genotoxic effect on the colorectal epithelial cells and predisposition to colorectal carcinogenesis. OUTLINE: Participants complete dietary questionnaire over 30-60 minutes and undergo collection of stool, blood, and tissue samples for analysis via sequencing and laser dissection.
Tracking Information
- NCT #
- NCT04666727
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Anusha Thomas, MD MD Anderson Cancer Center, Houston, Texas
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