FIbromyalgia anD GenetIcs Subgroups (FIDGIS)

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Description

This is an exploratory case control pathophysiology study of psychophysical (central sensitization assessment) and genetic (candidate gene panel) characteristics. The main objectives of this study are : Primary: Evaluate the central nociception sensitization characteristics and genetic determinants ...

This is an exploratory case control pathophysiology study of psychophysical (central sensitization assessment) and genetic (candidate gene panel) characteristics. The main objectives of this study are : Primary: Evaluate the central nociception sensitization characteristics and genetic determinants in fibromyalgic syndrome, comparing a group of patients to matched healthy controls. Secondary : 1) Characterize genetic predispositions of central sensitization in patients with FS compared to matched healthy controls, including confirmation of known genetic markers and potential identification of new genetic variants involved, 2) Compare in the area of central sensitization the population of patients with FS and matched healthy controls, 3) Compare in the domain of temporal summation the population of patients with FS and matched healthy controls, 4) Describe in the clinical field the characteristics of the FS patient population, 5) Compare in the areas of quality of life, anxiety/depression and comorbidities, characteristics of the FS patient population and matched healthy controls, 6) Compare epigenetic biomarkers of the FS patient population with healthy matched controls, 7) Study of the role of the gut microbiota in patients with FS (bio banking) 8) Compare in the areas of pain, sound and light sensitivity the population of patients with FS and matched healthy controls.

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