Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Breast Cancer
- Cardiotoxicity
- Cardiovascular Disease
- Endothelial Disfunction
- Neurovascular Disorder
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Diagnostic
Participation Requirements
- Age
- Between 45 years and 60 years
- Gender
- Only males
Description
The development of new drugs and different adjuvant therapeutic regimens, based on the combination of anthracycline (A) and cyclophosphamide (C), have contributed greatly to improve survival rate in breast cancer patients. Despite the clinical benefits of this therapy, AC treatment can cause cardiov...
The development of new drugs and different adjuvant therapeutic regimens, based on the combination of anthracycline (A) and cyclophosphamide (C), have contributed greatly to improve survival rate in breast cancer patients. Despite the clinical benefits of this therapy, AC treatment can cause cardiovascular acute and chronic changes. In a recent investigation, we observed that an acute AC chemotherapy session increases sympathetic nervous activity and blood pressure in patients with breast cancer. The present study aims to investigate the chronic effects of AC regimen on sympathetic nervous activity, peripheral vasoconstriction, endothelial microparticles and blood pressure, in women with breast cancer.
Tracking Information
- NCT #
- NCT04568161
- Collaborators
- Universidade Federal Fluminense
- Hospital Israelita Albert Einstein
- Investigators
- Principal Investigator: Carlos E Negrao, PhD Instituto do Coracao, HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
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