The Impact of Lung Recruitment Maneuver in 24-32 Weekers, and the Incidence of Bronchopulmonary Dysplasia
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Bronchopulmonary Dysplasia
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: The impact of lung recruitment maneuver in 24-32 weekers with assist-control volume guarantee mode to their hemodynamic status and the incidence of Bronchopulmonary dysplasiaMasking: Double (Participant, Outcomes Assessor)Masking Description: All babies wether they experience the intervention ofr not they can not tell to other peoples. Only The lab analyzer will be blind to the subject of study, other measurement can not be blind. Primary Purpose: Prevention
Participation Requirements
- Age
- Younger than 48 years
- Gender
- Both males and females
Description
description of the protocol : All Babies that meet inclusion criteria would immediately given surfactan. Babies will do echocardiography, blood gas analize, blood sample, transcutaneous monitor. After that babies will be randomized, the intervention group will get standart protocol + lung recruitmen...
description of the protocol : All Babies that meet inclusion criteria would immediately given surfactan. Babies will do echocardiography, blood gas analize, blood sample, transcutaneous monitor. After that babies will be randomized, the intervention group will get standart protocol + lung recruitment maneuver (LRM) and another group get standart protocol only. The lung recruitment maneuver (LRM) will be done by increasing of PEEP 0,2 cm H2O every 3 minutes, until reach the opening pressure. After that PEEP decrease gradually until get the closing pressure. Than the investigators will back to the opening pressure for 3 minutes, and the final PEEP will be put back 0,2 above closing pressure. After 3rd days (72 hours) babies, the investigators will exime serum levels of surfactan protein-D, CD-31+ and CD-42b- , blood gas , tc-pCO2 - PaCO2 , tcO2 index. After that babies will observe within 28 days to detect Bronchopulmonary dysplasia
Tracking Information
- NCT #
- NCT04555889
- Collaborators
- Indonesian Medical Education and Research Institute
- Investigators
- Principal Investigator: Dr. R. Adhi T Perma Iskandar, Sp.A (K) RSCMPerinatology
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