Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through ECGI
Last updated on July 2021Recruitment
- Recruitment Status
- Enrolling by invitation
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Cardiac Arrest
- Cardiac Arrhythmia
- Cardiac Death
- Congenital Heart Disease
- Heart Arrest
- Polymorphic Ventricular Tachycardia
- Sudden Cardiac Arrest
- Sudden Cardiac Death
- Sudden Cardiac Death Due to Cardiac Arrhythmia
- Ventricular Arrythmia
- Ventricular Fibrillation
- Ventricular Tachycardia
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Both groups (control and diseased) will undergo a body surface potential mapping and a cardiac + low dose CT-scan.Masking: Single (Care Provider)Masking Description: The treating physician is not informed about the results of the procedure.Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal card...
ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal cardiac electrophysiology, but also electrophysiological disorders and disease. The results strongly suggest that ECGI can play a pivotal role in further characterizing arrhythmia mechanisms, therefore could do so for VTAs, leading to diagnosis and treatment improvement. Moreover, ECGI seems to have the potential to detect arrhythmogenic substrate in individuals before their first event, offering the possibility to diagnose and treat patients before sudden cardiac arrest occurs. In the BREACH-ECGI study: ECGI will be used to noninvasively characterize the epicardial electrophysiological substrate and triggers of: Patients with (increased risk of) VTAs A control cohort. Results will be evaluated for increased mechanistic understanding and risk stratification. Moreover, clinical data of subjects will be gathered. These data will be analyzed to determine their prognostic value in terms of arrhythmia risk
Tracking Information
- NCT #
- NCT04548804
- Collaborators
- Jessa Hospital
- Investigators
- Not Provided
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