Countervail Cognitive and Cerebral Decline in Mild Cognitive Impairment Patients Using Non-medical Interventions
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Mild Cognitive Impairment
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: 2 experimental conditions (Music practice vs. Psychomotor training) and 1 active control condition (occupational therapy)Masking: Single (Participant)Masking Description: Patients will receive the information that 3 interventions to improve cognitive function in Mild Cognitive Impairment will be compared and that assignment to the interventions is random for scientific reasons.Primary Purpose: Treatment
Participation Requirements
- Age
- Between 60 years and 80 years
- Gender
- Both males and females
Description
Background Regular cognitive training can boost or maintain both cognitive and brain functions prey to decline with age. Such cognitive training is most often administered on a computer and in a lab setting. Yet, training methods based on everyday life experiences, like musical practice or dancing, ...
Background Regular cognitive training can boost or maintain both cognitive and brain functions prey to decline with age. Such cognitive training is most often administered on a computer and in a lab setting. Yet, training methods based on everyday life experiences, like musical practice or dancing, could be more effective following their complex and variable nature that may induce transfer effects to different cognitive domains more easily, and maintain motivation. Some evidence exists that also "body-mind exercises", Tai Chi or psychomotor practice may positively impact cognitive functioning in elderly. The investigators will examine the influence of active music practice and psychomotor training in MCI (Mild Cognitive Impairment) patients on cognitive performance and brain plasticity compared to an active control condition. Methods The research team will conduct a randomized intervention study in altogether 63 non-amnesic MCI patients without neurobiological markers of Alzheimer's disease (60-70 years), within 3 intervention groups: 1) Music practice; 2) Psychomotor training and 3) Social animation (active control group). The 3 training regimens will take place twice a week for 45 minutes over 6 months in small groups, provided by professionals in each field. Additionally, participants should exercise at home for ~30 minutes daily. Participants will be tested at 3 time points (baseline, 3, and 6 months) on cognitive and perceptual-motor aptitudes, subjective well-being and daily living activities as well as via wide-ranging cutting-edge functional and structural neuroimaging. Discussion The investigators intend to show that music practice and psychomotor exercise in small groups are well-targeted interventions to stabilize, reinforce or even improve cognitive, sensory-motor and brain functioning in the neglected population of non-amnesic MCI patients without Alzheimer biomarkers, and provoke benefits for daily life functioning, well-being and autonomy of these patients. The researchers expect differential benefits of both experimental interventions and hypothesize demonstrating that the slope of decline in this fragile population can be reversed via such non-medical interventions.
Tracking Information
- NCT #
- NCT04546451
- Collaborators
- University Hospital, Geneva
- University of Geneva, Switzerland
- Investigators
- Principal Investigator: Clara E. James, PhD University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland