Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Rheumatoid Arthritis
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 100 years
- Gender
- Both males and females
Description
The Specific Aims of This Study Are As Follows: Identify whether sputum anti-CCP predicts incident RA Determine the effect of inflammatory cytokines on the induction of NETosis in sputum neutrophils Determine the role of sputum macrophage phagocytosis in NET clearance <br> The knowledge gained from ...
The Specific Aims of This Study Are As Follows: Identify whether sputum anti-CCP predicts incident RA Determine the effect of inflammatory cytokines on the induction of NETosis in sputum neutrophils Determine the role of sputum macrophage phagocytosis in NET clearance <br> The knowledge gained from this study will improve the overall understanding of the development of RA. It is anticipated that these findings will improve the field's understanding of how best to screen for RA risk and target RA prevention. This study could support future lung-targeted prevention strategies for RA that could avoid the administration of systemic toxic therapies. Such potential prevention interventions could be implemented in subjects at risk for RA in order to prevent the irreversible joint damage that can occur in the later stages of clinically-apparent RA.
Tracking Information
- NCT #
- NCT04474392
- Collaborators
- National Institutes of Health (NIH)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- Investigators
- Principal Investigator: Kristen Demoruelle, MD, PhD University of Colorado, Denver
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