Mechanisms of Hypoglycemia in Patients Without Diabetes

Summary

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Description

Although there are several conditions which have been identified that cause, or contribute to hypoglycemia, diagnosis can be challenging, as the physiologic, and molecular mechanisms are incompletely understood. Additionally, treatment options are relatively limited, and often incompletely effective...

Although there are several conditions which have been identified that cause, or contribute to hypoglycemia, diagnosis can be challenging, as the physiologic, and molecular mechanisms are incompletely understood. Additionally, treatment options are relatively limited, and often incompletely effective and/or not well tolerated. Investigating the causative factors and mechanisms of hypoglycemia is important therefore in improving our understanding in order to develop new and more effective approaches to treatment. The current study aims to: more fully characterize clinical history and demographics in patients with diverse forms of hypoglycemia by creating and analyzing a patient database; for a subset of patients, characterize metabolic and hormonal responses to a standard meal; analyze DNA variants in individuals with hypoglycemia; analyze differences in the intestinal microbiome in individuals with hypoglycemia.

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