Detecting Lung Cancer Based on Exhaled Breath
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- 2000
Summary
- Conditions
- Carcinoma
- Lung Cancer
- Lung Neoplasms
- NSCLC
- Type
- Observational
- Design
- Observational Model: Case-ControlTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Endogenous volatile organic compounds (VOCs) can be derived from many different metabolic pathways. VOCs can be transported to the alveoli through the blood circulation and expelled by exhalation. Changes in VOCs production, clearance, and alterations in lung air-blood exchange functions can lead to...
Endogenous volatile organic compounds (VOCs) can be derived from many different metabolic pathways. VOCs can be transported to the alveoli through the blood circulation and expelled by exhalation. Changes in VOCs production, clearance, and alterations in lung air-blood exchange functions can lead to aberrant VOCs profiles in the exhaled breath. Testing exhaled breath has the advantages of being completely non-invasive and easy to collect, and has been considered as a perfect approach for disease diagnoses and therapeutic monitoring. Many clinical studies have found that VOCs in exhaled breath are closely related to disease status. Specific VOCs alterations have been identified in many tumors, especially lung cancer. In this study, we use a highly sensitive mass spectrometry to detect exhaled VOCs of lung cancer patients and healthy people. A lung cancer diagnosis model based on mass spectrometry data and support vector machine will be initially established and validated.
Tracking Information
- NCT #
- NCT04419207
- Collaborators
- Beijing Haidian Hospital
- Aerospace 731 Hospital
- Beijing Breatha Biological Technology Co., Ltd, Beijing
- The First Affiliated Hospital of Zhengzhou University
- Jiangsu Cancer Institute & Hospital
- Investigators
- Study Chair: Mantang Qiu, M.D Peking University People's Hospital Thoracic Surgery Department Principal Investigator: Zuli Zhou, M.D Peking University People's Hospital