Online Memory Intervention for Individuals With Traumatic Brain Injury
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Brain Injuries, Traumatic
- Brain Injury Traumatic Moderate
- Brain Injury Traumatic Severe
- Brain Injury, Chronic
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Participants are randomly assigned to either the experimental intervention (allocentric navigation training) or the active control intervention (educational videos).Masking: Triple (Participant, Investigator, Outcomes Assessor)Masking Description: Participants are blinded to whether they are completing the experimental or active control intervention.Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 55 years
- Gender
- Both males and females
Description
The memory impairments associated with moderate to severe traumatic brain injury can be debilitating to younger and older adults, and can prevent a person's return to work, school and social life. The "hippocampus" is a ubiquitously compromised memory brain structure in moderate-severe TBI. Unfortun...
The memory impairments associated with moderate to severe traumatic brain injury can be debilitating to younger and older adults, and can prevent a person's return to work, school and social life. The "hippocampus" is a ubiquitously compromised memory brain structure in moderate-severe TBI. Unfortunately, not only does the hippocampus sustain the damage at the time of injury, but researchers have identified that it shows continued atrophy in the months and years following injury. The investigators has developed a promising behavioural intervention for arresting this shrinkage, enhancing the integrity of the hippocampus - and improving memory function. It entails engagement in novel, continuous and challenging allocentric spatial navigation, that is, learning new routes of cities, and making a map in one's head of those routes for 1 hour/day, 5 days per week for a period of 16 weeks. N=87 participants will be randomized to either the intervention group or an active control group that will watch 3 TedTalk videos per day, 5 days a week for the same duration. An MRI scan and cognitive measures focusing on memory and spatial navigation will be conducted before and after participation.
Tracking Information
- NCT #
- NCT04331392
- Collaborators
- Ontario Neurotrauma Foundation
- Centre for Aging and Brain Health Innovation
- Investigators
- Principal Investigator: Robin E Green, PhD; CPsych Toronto Rehabilitation Institute Principal Investigator: Asaf Gilboa, PhD Baycrest Health Sciences
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