Exploring the Effects of Caltrate Supplement on the Chronic Course of Ulcerative Colitis Patients With Vitamin D Deficiency

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The research can be started only after approval by the Medical Ethics Committee of the Second Affiliated Hospital of Wenzhou Medical University. According to the "Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease" formulated by the Beijing Conference in 2018 as a standard, patients ...

The research can be started only after approval by the Medical Ethics Committee of the Second Affiliated Hospital of Wenzhou Medical University. According to the "Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease" formulated by the Beijing Conference in 2018 as a standard, patients with clear diagnosis of UC are collected. Exclusion criteria included pregnancy, breastfeeding, liver and kidney dysfunction, concurrent autoimmune diseases, and use of antiepileptic drugs or drugs metabolized by liver cytochrome P450 enzymes. Assess disease activity of UC participants based on the "Moya score". General information about participants with UC is collected. Detection of VDR gene polymorphisms using Snapshot technology. Serum C-reactive protein, erythrocyte sedimentation rate, white blood cells, albumin, creatinine, alanine aminotransferase, calcium and phosphorus levels are measured. The level of serum 25 (OH) D of participants is detected. Develop a treatment plan for participants. Participants are divided into two groups, one group is given oral Caltrate 0.6g / d, and the other group did not intervene. The above serum indicators are re-measured in the 12th month, and the condition of UC participants is also evaluated. Follow-up for 12 months. By comparing the above indicators, observe that in the Han population: Can Caltrate supplementation increase serum 25 (OH) D levels in patiens with UC? Can Caltrate supplementation improve the condition of patients with UC? Whether vitamin D gene polymorphisms affect the efficacy of Caltrate supplementation therapy? whether the effect of Caltrate on UC patients is affected by factors such as disease site, disease activity, treatment, etc .. Through statistical analysis, comprehensive analysis of the effectiveness and safety of Caltrate supplementation in Han patients with UC, and its relationship with vitamin D gene polymorphisms, providing a theoretical basis for further "precise treatment" intervention in inflammatory bowel disease.

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