RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Care, Palliative
- Respiratory Failure
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Participants will be randomised for 2 groups: high flow nasal cannula or standard care with no crossover between them.Masking: Single (Outcomes Assessor)Masking Description: Outcome assessors will have no access to randomisation list and won't be able to guess which group participant was allocated to.Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Do-not-intubate (DNI) is usually established in cases where endotracheal intubation (ETI) is considered disproportionate to prognosis and/or incompatible with the expression of wishes and values of the patient. Regardless of the profile of this care plan offered to patients with DNI, the control of ...
Do-not-intubate (DNI) is usually established in cases where endotracheal intubation (ETI) is considered disproportionate to prognosis and/or incompatible with the expression of wishes and values of the patient. Regardless of the profile of this care plan offered to patients with DNI, the control of dyspnea is one of its central objectives. The approach to dyspnea includes pharmacological measures such as opioids and non-pharmacological measures, such as oxygen therapy and Non-Invasive Ventilation, and more recently, the high flow nasal catheter (HFNC). HFNC provides high flow of heated and humidified mixed gas through a nasal cannula. In addition to the ability to generate high flows and supplemental oxygen, HFNC may generate a low level of positive airway pressure, may decrease dead space ventilation and may contribute to better patient comfort, such as the possibility of oral feeding while undergoing treatment, performing oral hygiene and allowing conversation and interaction with family members. This pilot study aims to evaluate the efficacy of HFNC in reducing dyspnea and improving comfort in patients with Acute Respiratory Failure (ARF) and DNI order.
Tracking Information
- NCT #
- NCT04269681
- Collaborators
- Ministry of Health, Brazil
- Fisher and Paykel Healthcare
- Investigators
- Study Director: Alexandre B Cavalcanti, MD Hospital do Coracao Principal Investigator: Lara P Kretzer, MD HU UFSC Principal Investigator: Leticia Kawano-Dourado, MD Hospital do Coracao Principal Investigator: Israel S Maia, MD Hospital do Coracao Study Chair: Fernando Zampieri, MD Hospital do Coracao
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