Racial Differences in Serum Sodium and Blood Pressure Regulation
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Blood Pressure
- Cardiovascular Risk Factor
- Racial Disparities
- Sodium Excess
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Crossover AssignmentIntervention Model Description: The intervention is to provide subjects with either a low sodium meal (140 mg sodium) and a high sodium meal (2500 mg sodium), in a randomized order.Masking: Single (Investigator)Masking Description: The experimenter will be blinded to what sodium condition the participant is in, and all data analysis will be conducted blinded to the condition as well.Primary Purpose: Prevention
Participation Requirements
- Age
- Between 19 years and 75 years
- Gender
- Both males and females
Description
The investigators aim to study racial differences in cardiovascular responses to high dietary sodium. An overwhelming majority of Americans consume more dietary sodium than what is recommended by the American Heart Association and the Dietary Guidelines for Americans. The investigators recently publ...
The investigators aim to study racial differences in cardiovascular responses to high dietary sodium. An overwhelming majority of Americans consume more dietary sodium than what is recommended by the American Heart Association and the Dietary Guidelines for Americans. The investigators recently published data demonstrating that compared to white individuals, 1) black individuals have augmented increases in serum sodium concentration to a hypertonic saline infusion; and 2) exhibit higher blood pressure for a given serum sodium. In this proposal, the investigators will translate these findings by comprehensively assessing neurovascular responses to acute (single meal) high dietary sodium. The central hypothesis is that high dietary sodium influences sympathetic nerve activity similarly in black and white individuals; however, diminished vasodilator capacity and augmented sympathetic transduction (vasoconstrictor responses to sympathetic nerve bursts) contribute to exaggerated blood pressure dysregulation in black individuals. The investigators will also determine the role of lifestyle factors (i.e., sleep, physical activity, and nutrition) on potential baseline racial differences in cardiovascular function.
Tracking Information
- NCT #
- NCT04244604
- Collaborators
- University of Delaware
- Investigators
- Principal Investigator: Austin T Robinson, PhD Auburn University
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