Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Chronic Kidney Diseases
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 75 years
- Gender
- Both males and females
Description
The study will have three stages. Stage 1: 45 people with CKD from nine UKRIN centres will undergo multiparametric MRI to test patient tolerance, data completeness and central data collection processes. Stage 2: A multicentre, prospective cohort study of 450 people with CKD, collecting multiparametr...
The study will have three stages. Stage 1: 45 people with CKD from nine UKRIN centres will undergo multiparametric MRI to test patient tolerance, data completeness and central data collection processes. Stage 2: A multicentre, prospective cohort study of 450 people with CKD, collecting multiparametric renal MRI at baseline and 2 years. Long-term outcomes will be determined with efficient tracking of kidney failure events via the UK Renal Registry at 5 and 10 years. Stage 3: A mechanistic sub-study of 45 patients (from Stage 2) who have had a routine renal biopsy. Detailed comparisons will be made between multiparametric MRI and histopathological changes. Tissue blocks will undergo quantitative analysis of fibrosis, capillary density and inflammation using immunohistochemistry techniques.
Tracking Information
- NCT #
- NCT04238299
- Collaborators
- University of Nottingham
- Queen Elizabeth University Hospital Glasgow
- Royal Infirmary of Edinburgh
- University of Edinburgh
- Newcastle University
- Newcastle-upon-Tyne Hospitals NHS Trust
- University of Leeds
- The Leeds Teaching Hospitals NHS Trust
- Sheffield Teaching Hospitals NHS Foundation Trust
- University College, London
- University of Cambridge
- University of Sheffield
- Cambridge University Hospitals NHS Foundation Trust
- Salford Royal NHS Foundation Trust
- Investigators
- Not Provided