A Cholesterol Lowering Therapy of Non-invasive Focused High-intensity Ultrasound Mediated Perirenal Fat Modification
Last updated on July 2021Recruitment
- Recruitment Status
- Not yet recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Arteriosclerotic Cardiovascular Disease
- Dyslipidemias
- Hypercholesteremia
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: This is a randomized, single-blind,sham-controlled pilot study.The ratio of the treatment group versus sham-control group was 1:2.Masking: Triple (Participant, Care Provider, Investigator)Masking Description: The masking range includes: study participants, most researchers (including the study leader; subjects screening researchers; case follow-up researchers; sonographers; CT scanners, members of the clinical endpoint identification committee,and etc.) except for the study statistical analysts and the therapy operatorsPrimary Purpose: Treatment
Participation Requirements
- Age
- Between 40 years and 70 years
- Gender
- Both males and females
Description
It has been known that the accumulation of visceral fat is associated with dyslipidemia and the occurrence of arteriosclerotic cardiovascular disease(ASCVD).Peri-renal fat is a special type of visceral fat which is different in histology, physiology, and functions. The positon of peri-renal fat is m...
It has been known that the accumulation of visceral fat is associated with dyslipidemia and the occurrence of arteriosclerotic cardiovascular disease(ASCVD).Peri-renal fat is a special type of visceral fat which is different in histology, physiology, and functions. The positon of peri-renal fat is more stable than other visceral fat,which might be influenced by breath or body position changes.Studies have found that perirenal fat is an early predictor of ASCVD, and its accumulation is closely related to the occurrence and development of ASCVD.Therefore, the reduction of visceral fat,especially peri-renal fat , has a sufficient scientific basis for treating dyslipidemia and reducing the occurrence of cardiovascular disease. In investigators' previous experiments, surgical ablation of bilateral perirenal adipose tissue led to long-term, effective reduction of serum cholesterol in high-fat diet rats and alleviated the cardiovascular injury,based on which,in this study the investigators provide a novel non-invasive therapy of high-intensity focused ultrasound mediated perirenal fat modification to lower the serum cholesterol and protect subjects from ASCVD.
Tracking Information
- NCT #
- NCT04223557
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Xiangqing Kong, M.D.&PhD The First Affiliated Hospital with Nanjing Medical University
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