Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Healthy Lifestyle
- Men
- Obese
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Sequential AssignmentMasking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 40 years
- Gender
- Only males
Description
The investigators will recruit 20 normal weight, active men and 80 obese, inactive men to compare their sperm epigenome at their baseline state. The investigators will randomize the 80 obese, inactive men to intervention or no intervention for 12 weeks:1) observation with clinic visits; 2) low fat/l...
The investigators will recruit 20 normal weight, active men and 80 obese, inactive men to compare their sperm epigenome at their baseline state. The investigators will randomize the 80 obese, inactive men to intervention or no intervention for 12 weeks:1) observation with clinic visits; 2) low fat/low caloric diet; 3) supervised periodized strength and endurance training; and 4) low fat/ low caloric diet plus exercise training. The investigators will compare changes in their sperm epigenome within each group before and after intervention, between groups after intervention including the non-obese,active men at baseline. The investigators will follow the 80 men in the intervention groups and re-examined their sperm epigenome at 12 weeks and then another 24 weeks after cessation of treatment.
Tracking Information
- NCT #
- NCT04175678
- Collaborators
- National Institutes of Health (NIH)
- Investigators
- Principal Investigator: Christina Wang, MD The Lundquist Institute
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