Effect of Prebiotics on Function and Pain in Patients With Osteoarthritis and Obesity Obesity
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Obesity
- Osteo Arthritis Knee
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: Triple (Participant, Investigator, Outcomes Assessor)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 30 years and 75 years
- Gender
- Both males and females
Description
Primary outcome: 1. To determine the change in knee joint function and physical performance in adults with obesity and knee osteoarthritis treated for 6 months with oligofructose-enriched inulin or placebo. Secondary outcomes: To determine the change in knee pain in adults with obesity and knee oste...
Primary outcome: 1. To determine the change in knee joint function and physical performance in adults with obesity and knee osteoarthritis treated for 6 months with oligofructose-enriched inulin or placebo. Secondary outcomes: To determine the change in knee pain in adults with obesity and knee osteoarthritis treated for 6 months with oligofructose-enriched inulin or placebo. To examine the change in body composition (fat mass and lean mass) in participants treated with oligofructose-enriched inulin or placebo. To evaluate the change in quality of life in participants treated with oligofructose-enriched inulin or placebo. To gain a mechanistic understanding of the influence of oligofructose-enriched inulin supplementation in metabolic OA through examination of gut microbiota composition and short-chain fatty acid concentrations. To gain a mechanistic understanding of the influence of oligofructose-enriched inulin supplementation in metabolic OA through examination of serum inflammatory and metabolomics markers.
Tracking Information
- NCT #
- NCT04172688
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Raylene A Reimer, PhD, RD University of Calgary
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