Oltipraz for Liver Fat Reduction in Patients With Non-alcoholic Fatty Liver Disease Except for Liver Cirrhosis
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Non Alcoholic Fatty Liver Disease
- Type
- Interventional
- Phase
- Phase 3
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: Single (Participant)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 19 years and 75 years
- Gender
- Both males and females
Description
Dithiolethiones, a novel class of adenosine monophosphate-activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition. And it is well known that the modulation of S6K1 by oltipraz inhibited the development of insulin resis...
Dithiolethiones, a novel class of adenosine monophosphate-activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition. And it is well known that the modulation of S6K1 by oltipraz inhibited the development of insulin resistance and hyperglycemia through the AMPK-S6K1 pathway.Also some research reported that LXRg (a member of the nuclear hormone receptor)-mediated increases in SREBP-1c (the sterol regulatory element-binding protein-1c gene) promote the expression of lipogenic genes and enhance fatty acid synthesis and oltipraz inhibits LXRg and SREBP-c. Therefore, Oltipraz inhibits fatty acid synthesis through AMPK-S6K1 pathway and LXRg-SREBP-1c pathway in liver.
Tracking Information
- NCT #
- NCT04142749
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Yun-Jun Kim, MD.PhD Seoul Nat'l Uni. Hospital Principal Investigator: Changuk Kim, MD.PhD The Catholic University of Korea, Uijeongbu ST. Mary's Hospital Principal Investigator: Gapjin Chun, MD.PhD Gangneung Asan Medical Center Principal Investigator: Taehui Lee, MD.PhD Kunyang University Hospital Principal Investigator: Byeongguk Jang, MD.PhD Keimyung University Dongsan Medical Center Principal Investigator: Seonguk Lee, MD.PhD Dong-A University Hospital Principal Investigator: Byeonggwan Kim, MD.PhD Boramae Hospital Principal Investigator: Yeongseok Kim, MD.PhD Soonchunhyang University Hospital Principal Investigator: Jaeyeong Chang, MD.PhD Soonchunhyang University Hospital Principal Investigator: Jaeyeong Jung, MD.PhD Ajou University School of Medicine Principal Investigator: Hyeonung Lee, MD.PhD Yonsei University Gangnam Severance Hospital Principal Investigator: Doyeong Kim, MD.PhD Severance Hospital Principal Investigator: Munyeong Kim, MD.PhD Wonju Severance Christian Hospital Principal Investigator: Junseong Lee, MD.PhD Inje University Ilsan Baek Hospital Principal Investigator: Jinu Lee, MD.PhD Inha University Hospital Principal Investigator: Hyeongjun Kim, MD.PhD Chung-Ang University Hosptial, Chung-Ang University College of Medicine Principal Investigator: Sanghun Park, MD.PhD Hallym University Gangnam Sungsim Hospital Principal Investigator: Daewon Jun, MD.PhD Hanyang University Principal Investigator: Chun Kyun Lee, MD.PhD National Health Insurance Service Ilsan Hospital
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