The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Bladder Neoplasm
- Bladder Cancer
- Oligometastases
- Liver Metastases
- Prostate Neoplasm
- Brain Cancer
- Brain Tumor
- Breast Cancer
- Breast Tumor
- Pancreatic Tumor
- Rectal Tumor
- Esophageal Cancer
- Head and Neck Tumor
- Neoplasms
- Tumor
- Gynecologic Tumor
- Lung Cancer
- Pancreatic Cancer
- Head and Neck Neoplasms
- Esophageal Neoplasm
- Esophageal Tumor
- Rectal Cancer
- Prostate Cancer
- Esophagus Cancer
- Gynecologic Cancer
- Lung Neoplasm
- Prostate Tumor
- Liver Cancer
- Lung Tumor
- Pancreatic Neoplasms
- Esophagus Tumor
- Liver Neoplasms
- Head and Neck Cancer
- Rectal Neoplasms
- Esophagus Neoplasm
- Oncology
- Radiation Toxicity
- Quality of Life
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Rationale: Radiation therapy has become indispensable in cancer treatment. However, it is associated with severe side effects. Innovation in radiation therapy has resulted in the development of MR-guided radiation therapy (MRGRT) which allows high precision radiotherapy under real time MR visualizat...
Rationale: Radiation therapy has become indispensable in cancer treatment. However, it is associated with severe side effects. Innovation in radiation therapy has resulted in the development of MR-guided radiation therapy (MRGRT) which allows high precision radiotherapy under real time MR visualization. High precision MRGRT has the potential of dose escalation and margin reduction and may potentially lead to higher cure rates and less toxicity. MRGRT can be delivered by the MRI guided Linear Accelerator (MR-Linac) which integrates a state-of-the-art linear accelerator, 1.5T diagnostic quality MRI and an online adaptive workflow. Objective: The Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-Linac Study (MOMENTUM) aims to accelerate the technical and clinical development of Anatomic and Biologic MRGRT and facilitate the evidence-based introduction of the MR-Linac into clinical practice. In MOMENTUM, technical and clinical data are gathered in order to optimize software, evaluate treatment outcomes, toxicities and progression free, disease free, and overall survival per disease site, and create a repository of anatomical and biological MR sequences to develop new features. Study design: A multi-institutional, international observational cohort study. Study population: Cancer patients ? 18 years receiving treatment and/or imaging on an MR-Linac machine are eligible for enrollment. Main study parameters/endpoints: MOMENTUM will collect technical and clinical patient data. The technical patient data is defined as data generated by (the use of) the MR-Linac and will include data collection during scans performed during routine care as well as research MRIs. Clinical data will be categorized into six classes: demographic, disease characteristics, treatment classifiers, toxicity outcomes, cancer control outcomes and PROs.
Tracking Information
- NCT #
- NCT04075305
- Collaborators
- The Netherlands Cancer Institute
- Sunnybrook Health Sciences Centre
- M.D. Anderson Cancer Center
- The Christie NHS Foundation Trust
- Royal Marsden NHS Foundation Trust
- Medical College of Wisconsin
- Elekta Limited
- Investigators
- Principal Investigator: Helena M Verkooijen, Prof, Dr Universitair Medical Centre Utrecht
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