Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
Summary
- Conditions
- Adolescent Obesity
- Beta Cell Dysfunction
- Gut Hormones
- Gut Microbiome
- Immunity
- Inflammation
- Insulin Resistance
- Metabolic Problems
- Obesity
- Prediabetes
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 12 years and 18 years
- Gender
- Both males and females
Description
This study proposes to characterize inflammatory biomarkers, insulin resistance and fecal microbiome composition in obese/pre-diabetic adolescents after glucose ingestion, followed by an oral fat tolerance test on a separate visit. Lipoprotein abnormalities and intestinal biomarkers, post-lipid inge...
This study proposes to characterize inflammatory biomarkers, insulin resistance and fecal microbiome composition in obese/pre-diabetic adolescents after glucose ingestion, followed by an oral fat tolerance test on a separate visit. Lipoprotein abnormalities and intestinal biomarkers, post-lipid ingestion, will also be evaluated. The primary aim is to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in the adolescent population.
Tracking Information
- NCT #
- NCT04031222
- Collaborators
- University of Toronto
- University of Guelph
- Sunnybrook Health Sciences Centre
- Investigators
- Principal Investigator: Jill K Hamilton, MD The Hospital for Sick Children
Get Well Soon