Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital

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Sepsis is a physiologic, pathologic, and biochemical abnormalities induced by infection. sepsis is considered as a leading cause of mortality and critical illness worldwide by many conservative estimates. sepsis epidemiology studies worldwide revealed a highly variable incidence of 13-300 per 100,00...

Sepsis is a physiologic, pathologic, and biochemical abnormalities induced by infection. sepsis is considered as a leading cause of mortality and critical illness worldwide by many conservative estimates. sepsis epidemiology studies worldwide revealed a highly variable incidence of 13-300 per 100,000 inhabitants per year for severe sepsis and 11 per 100,000 inhabitants per year for septic shock . factors such as advancing age, immunosuppression and multi-drug-resistant infection play a role in increasing incidence of sepsis during recent decades . patients who survive sepsis often have long-term physical, psychological, and cognitive disabilities with significant health and social implications. Patients with diabetes mellitus have an increased risk of developing infections and sepsis and they constitute 20.1-22.7% of all sepsis patients. Infection also remains an important cause of death in diabetics. The prevalence of diabetes mellitus in Intensive Care Unit patients is as high as 30%, And such patients are at increased risk of experiencing in-hospital Complications, compared to patients without diabetes. Infective complications may be reduced with lower blood glucose concentrations Moreover, in critically ill patients without diabetes, Hyperglycemia is associated with increased mortality, risk of infection, Kidney injury and cardiovascular complications. Moreover, diabetes is a major risk factor for both Acute Kidney Injury and sepsis. Sepsis also is a major cause of Acute Kidney Injury, which develops in one-fourth of all patients with sepsis and half of patients with bacteremia or shock . Sepsis-related Acute Kidney Injury is associated with high mortality rates of up to 70%.

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