Overcoming Chemoresistance in Advanced Ovarian Cancer Via Targeting Hypoxia
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Epithelial Ovarian Cancer
- Fallopian Tube Cancer
- Hypoxia
- Peritoneal Carcinoma
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Parallel AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 79 years
- Gender
- Only males
Description
MORE SPECIFIC AIMS To validate the feasibility of PET-tracer EF5 in EOC imaging. Quantify the amount and exact locations of hypoxic tumors in EOC patients using herein developed protocol and tracers (18F-EF5 and 18F-FDG) in diagnostic and neoadjuvant settings. Measure the non-cancer related EF5 accu...
MORE SPECIFIC AIMS To validate the feasibility of PET-tracer EF5 in EOC imaging. Quantify the amount and exact locations of hypoxic tumors in EOC patients using herein developed protocol and tracers (18F-EF5 and 18F-FDG) in diagnostic and neoadjuvant settings. Measure the non-cancer related EF5 accumulation spots and establish the potential pitfalls in abdominal EF5 imaging Establish a method to verify hypoxic locations with 18F-EF5-PET/CT information during the operation. Develop and validate a model that predicts chemotherapy response based on functional imaging information. To reveal hypoxia related alterations in collected tissue samples (i.e. altered DNA damage repair, altered mitochondrial respiratory functioning, overexpression of hypoxia response elements etc)
Tracking Information
- NCT #
- NCT04001023
- Collaborators
- Not Provided
- Investigators
- Not Provided
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