Fluorescence Imaging of Disease Activity in IBD and Rheumatoid Arthritis Using OTL38

Fluorescence Imaging for the Evaluation of Disease Activity in IBD and Rheumatoid Arthritis Using the Fluorescent Tracer OTL38 Targeting the Folate ? Receptor: a Single-center Pilot Study

Rheumatoid Arthritis (RA) and inflammatory bowel disease (IBD) are both inflammatory diseases caused by a persistent chronic inflammation. A chronic inflammation is caused by the absence of the inflammation response resolution. Currently, diagnosis and disease activity measurements are based on symptom-based scores or on anatomical imaging devices. Both methods are unable to detect both early stages of the disease and early changes in inflammation as a reaction to treatment. Objective, early measures of inflammation could improve diagnosis and in the future therapeutic outcomes by identifying early therapy responders and non-responders. The aim of this feasibility study is to evaluate the safety and feasibility of the near infrared (NIR) tracer OTL38 for monitoring disease activity in inflammatory diseases rheumatoid arthritis and inflammatory bowel disease. The hypothesis is that OTL38 will accumulate in inflamed tissue due to the increased presence of activated macrophages expressing the folate beta receptor, enabling better visualization and monitoring of the inflammation. It is expected that this approach can improve treatment and diagnosis of patients with inflammatory disease.

Fluorescence Imaging of Disease Activity in IBD and Rheumatoid Arthritis Using OTL38

Recruitment

Summary

Participation Requirements

Description

Tracking Information