KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 7000
Summary
- Conditions
- Crescentic Glomerulonephritis
- Focal Segmental Glomerulosclerosis
- Glomerular Disease
- IgA Nephropathy
- Lupus Nephritis
- Membranous Nephropathy
- Minimal Change Disease
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Younger than 125 years
- Gender
- Both males and females
Description
Glomerulonephritis (GN) such as Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), Membranous nephropathy (MN), and Immunoglobulin A nephropathy (IgAN) has quite a common clinical presentation often results in renal insufficiency which generates an enormous individual and socia...
Glomerulonephritis (GN) such as Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), Membranous nephropathy (MN), and Immunoglobulin A nephropathy (IgAN) has quite a common clinical presentation often results in renal insufficiency which generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis is uncertain. Recently, along with advances in molecular analysis and computational bioinformatics, genomic data from human renal biopsies could provide a strong foundation for the future of precision medicine in nephrology. In response to a request for applications by the Ministry of Health and Welfare of Korea for the creation of Clinical Research Registry, a number of universities joined together to establish Korean Kidney Biopsy Network (KORNERSTONE). Through this Network the investigators hope to understand the fundamental biology of glomerulonephritis and aim to bank long-term observational data and corresponding biological data including genomic data from kidney tissues, and kidney pathologic data which is digitalized This database is archived to a web-based platform to access easily and further enrich for researchers. ============ <Patient clinical data will be collected as follows> Blood tests: CBC, Chemistry (Ca, P, Glucose, Total protein, Albumin, Uric acid), Electrolyte, Renal function (BUN, Creatinine, eGFR), Liver function (AST, ALT) Immunologic blood tests: Complement 3, Complement 4, ASO, RF, Cryoglobulin, dsDNA, ANA Urine tests: Urinalysis, Urine protein, Urine albumin, Urine creatinine Radiologic tests: Kidney USG, Abdominal-pelvis computed tomography Pathologic results Treatment informations: treatment status, drug type, treatment duration Quality of life questionnaire: Kidney Disease and Quality of Life Short Form survey (adults), PedsQL 4.0 Generic Core Scales (pediatrics) Dietary questionnaire
Tracking Information
- NCT #
- NCT03929887
- Collaborators
- Chung-Ang University Hosptial, Chung-Ang University College of Medicine
- KangWon National University Hospital
- Keimyung University Dongsan Medical Center
- SMG-SNU Boramae Medical Center
- Seoul National University Bundang Hospital
- Severance Hospital
- Ministry of Health & Welfare, Korea
- Investigators
- Study Director: Dong Ki Kim, MD, PhD Seoul National University Hospital