Analysis of the Severity and Prognosis of Pulmonary Hypertension Associated With Bronchiectasis.

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The patients with bronchiectasis during the past five years were retrospectively analyzed. Demographic factors (gender, age, smoking history and body mass index), clinical indicators (signs and symptoms), sputum culture results (pseudomonas aeruginosa), brain natriuretic peptide and imaging (scope a...

The patients with bronchiectasis during the past five years were retrospectively analyzed. Demographic factors (gender, age, smoking history and body mass index), clinical indicators (signs and symptoms), sputum culture results (pseudomonas aeruginosa), brain natriuretic peptide and imaging (scope and type of bronchiectasis), pulmonary function index, pulmonary artery systolic pressure through doppler ultrasound, prognosis, the number of exacerbation in the past year and hospitalization days will be analyzed. Different groups: bronchiectasis with pulmonary hypertension and bronchiectasis without pulmonary hypertension according to the results of doppler ultrasound; mild (40mmHg ? SPAP < 60mmHg), moderate (60mmHg ? SPAP < 80mmHg), and severe (80mmHg ? SPAP) group according to SPAP level; survival and death groups according to the results of follow-up. Above indexes between the different groups will be analyzed to explore which factors can be independent factors combined with bronchiectasis pulmonary hypertension, the degree of pulmonary artery systolic pressure, and the prognosis of patients. 60 bronchiectasis patients will be enrolled in a prospective study, and divided into two groups (bronchiectasis with pulmonary hypertension and bronchiectasis without pulmonary hypertension). Interleukin 1 beta, IL - 18, endothelin 1 in peripheral blood and bronchoalveolar lavage from patients will be examined through enzyme linked immunosorbent assays (ELISA). NLRP3 inflammasome, ASC, caspase 1 mRNA expression from peripheral blood mononuclear cells and mucous membrane of the bronchial lung tissues will be examined through RT-PCR method. The correlation indexes between different groups were compared and analyzed to explore which factors were associated with bronchiectasis and pulmonary hypertension.

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