The Tracking Molecular Evolution for NSCLC (T-MENC) Study
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Adenocarcinoma of Lung
- Lung Cancer
- Lung Neoplasms
- Nonsmall Cell Lung Cancer
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 80 years
- Gender
- Both males and females
Description
In the study, 200 of stage IB,II and IIIA non-small cell lung cancer patients obtained radical resection will be recruited. All the patients will receive biopsy genotype assay and ctDNA liquid biopsy. The abundance of mutations of ctDNA was tracked at 4 time points, including: st: 10 Days after pati...
In the study, 200 of stage IB,II and IIIA non-small cell lung cancer patients obtained radical resection will be recruited. All the patients will receive biopsy genotype assay and ctDNA liquid biopsy. The abundance of mutations of ctDNA was tracked at 4 time points, including: st: 10 Days after patients received radical resection. nd: When patients finished the chemotherapy or target drug delivery two cycles. rd: 10 Days after patients finished the chemotherapy or target drug delivery four cycles. th: When tumor recrudescence / 2 years after radical resection. Tumor genomic clonal evolution was assessed by analyzing the relative abundance of mutations in plasma circulating tumor DNA (ctDNA).
Tracking Information
- NCT #
- NCT03838588
- Collaborators
- Xuanwu Hospital, Beijing
- Investigators
- Study Chair: Yi Zhang, MD Xuanwu Hospital, Beijing Principal Investigator: Yao guang Sun, MD Beijing Hospital Principal Investigator: Jie Li, MD Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China +86-139 1189 2587 lijie821cn@163.com Principal Investigator: Hong Zhang, MD The First Hospital of Jilin University Principal Investigator: Zhi qiang Wang, MD Tangshan People's Hospital Principal Investigator: Ming He, MD Beijing Chest Hospital, Capital Medical University Principal Investigator: Zi dan Wang, MD Beijing Chest Hospital, Capital Medical University Principal Investigator: Li jun Liu, MD Hebei General Hospital Principal Investigator: Kang Shao, MD Cancer Institute and Hospital, Chinese Academy of Medical Sciences Principal Investigator: Chao yang Liang China-Japan Friendship Hospital
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