Pediatric Obesity Related Metabolite Profile and Gut Microbiota
Last updated on July 2021Recruitment
- Recruitment Status
- Enrolling by invitation
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Obesity, Childhood
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Factorial AssignmentIntervention Model Description: Intervention arm: every obese children will have individualized education program about diet control and exercise in usual life. Control arm: normal weight childrenMasking: None (Open Label)Primary Purpose: Supportive Care
Participation Requirements
- Age
- Younger than 18 years
- Gender
- Both males and females
Description
Many recent studies have suggested that dysbiosis of the gut microbiome might related to obesity. There is growing evidence that the composition of gut microbiome changes in childhood obesity compared to normal-weight children, and it is attracting attention as an adjustable environmental factor in ...
Many recent studies have suggested that dysbiosis of the gut microbiome might related to obesity. There is growing evidence that the composition of gut microbiome changes in childhood obesity compared to normal-weight children, and it is attracting attention as an adjustable environmental factor in obesity treatment. It has been reported that gut microbiome could be changed due to environmental influences such as diet and exercise. In this study, the investigators aimed to observe changes in the gut microbial composition before and after the weight-loss intervention, including dietary control and exercise, in obese children. The main metabolites produced by gut microbiome, short chain fatty acids (SCFAs) would be also analysed to investigate the relationship with gut microbiome and with weight-loss intervention. Intervention is not performed for normal-weight children, and samples from normal-weight children will be used as a control for gut microbiome and biochemical tests.
Tracking Information
- NCT #
- NCT03812497
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Ky Young Cho, Ph.D. Kangnam Sacred Heart Hospital, Hallym University College of Medicine