Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
Same as current

Summary

Conditions
  • Endotoxemia
  • Glucose Metabolism Disorders
  • Insulin Resistance
  • Metabolic Syndrome
Type
Interventional
Phase
Not Applicable
Design
Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Primary Purpose: Prevention

Participation Requirements

Age
Between 18 years and 70 years
Gender
Both males and females

Description

It is now recognized that overweight individuals have altered microbiota which could lead to intestinal barrier defects and chronic inflammation disorders. Polyphenols such as Proanthocyanidins may modulate the gut microbiota thereby providing beneficial effects on metabolic health. Inulin is a well...

It is now recognized that overweight individuals have altered microbiota which could lead to intestinal barrier defects and chronic inflammation disorders. Polyphenols such as Proanthocyanidins may modulate the gut microbiota thereby providing beneficial effects on metabolic health. Inulin is a well known prebiotic that could stimulate growth of favorable bacteria in the gut. The overall goal is to determine the efficacy and synergy of a supplement of polyphenols from cranberry extract with or without a supplement of inulin from agaves to reduce chronic inflammation and endotoxemia and to improve glucose metabolism and insulin sensitivity by modulating microbiota of overweight human subjects with metabolic syndrome symptoms.

Tracking Information

NCT #
NCT03800277
Collaborators
  • Ministry of Agriculture, Fisheries and Food, Quebec
  • Ministry of economic development, innovation and export trade, Quebec
  • Fruit d Or, Quebec
  • Diana Food, Symrise
  • Atrium Innovations
  • NutriAgaves, Mexico
  • Nestlé
Investigators
Principal Investigator: Hélène Jacques, PhD Institute of nutrition and functional foods, Laval University Study Director: Yves Desjardins, PhD Institute of nutrition and functional foods, Laval University