TCR-T Cell for Immunotherapy of Lung Cancer and Other Solid Tumors
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Nonsmall Cell Lung Cancer
- Solid Tumor, Adult
- Type
- Interventional
- Phase
- Phase 1
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 75 years
- Gender
- Both males and females
Description
Choose appropriate patients with advanced lung cancer or other solid tumors, with written consent for this study; Perform biopsy to obtain tissue for organoids and TILs, coculture to screening anti-tumor T cells, select monoclonal T cells; Clone TCR sequence; collect PBMCs from the blood of the pati...
Choose appropriate patients with advanced lung cancer or other solid tumors, with written consent for this study; Perform biopsy to obtain tissue for organoids and TILs, coculture to screening anti-tumor T cells, select monoclonal T cells; Clone TCR sequence; collect PBMCs from the blood of the patients, isolate and activate the T cells and produce TCR-T cells; Test the quality and killing activity of the TCR-T cells and then transplant back the patients via systemic (vein and/or artery) or local injections, and follow up closely to collect related clinical data as needed; Evaluate the clinical results as needed.
Tracking Information
- NCT #
- NCT03778814
- Collaborators
- First Affiliated Hospital of Jinan University
- Investigators
- Principal Investigator: Zhenfeng Zhang, MD,PhD Second Affiliated Hospital of Guangzhou Medical University
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