Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 80
Summary
- Conditions
- Acute Lung Injury
- ARDS
- Extracorporeal Membrane Oxygenation
- Lung Diseases
- Lung Injury, Acute
- Respiratory Distress Syndrome
- Respiratory Tract Diseases
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Comparison of 2 groupsMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 99 years
- Gender
- Both males and females
Description
The aim of this study is to assess the effect of a rigorous low breathing frequency and ultra-low tidal volume ventilation strategy on clinical outcome, compared to standard ventilator settings following the recent guidelines in patients with severe ARDS treated with ECMO. The hypothesis is that a l...
The aim of this study is to assess the effect of a rigorous low breathing frequency and ultra-low tidal volume ventilation strategy on clinical outcome, compared to standard ventilator settings following the recent guidelines in patients with severe ARDS treated with ECMO. The hypothesis is that a low breathing frequency and ultra-low tidal volume ventilation strategy is more protective for the ARDS challenged lung and reduces the duration of mechanical ventilation and so increases the ventilator free days in patients with severe ARDS treated with ECMO.
Tracking Information
- NCT #
- NCT03764319
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Roman Ullrich, Ao.Univ.Prof. Department of Anesthesia and Intensive Care
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