Glucocorticoid-induced Tumour Necrosis Factor Receptor Related Protein (GITR) in Rheumatoid Arthritis

Summary

Participation Requirements

Description

Technical design: Study design: a longitudinal observational cohort study. This study will be carried out on two groups: Group (I): fifty early onset rheumatoid arthritis (RA) patients fulfilled the 2010 American college of rheumatology (ACR) - European league against rheumatism (EULAR) classificati...

Technical design: Study design: a longitudinal observational cohort study. This study will be carried out on two groups: Group (I): fifty early onset rheumatoid arthritis (RA) patients fulfilled the 2010 American college of rheumatology (ACR) - European league against rheumatism (EULAR) classification criteria for RA [11]. Group (II): Twenty healthy individuals of matching age and sex as control group. Both groups will be recruited from the in-patients and out-patients' clinic of the Rheumatology, Rehabilitation& Physical Medicine Department, Benha University Hospital. All patients will be evaluated at baseline at 6 months follow up using: (A) Clinical evaluation 1. Complete history taking. 2. Thorough clinical examination. 3. Disease activity using DAS28 [12] (B) Laboratory assessment: All patients will be subjected to the following measurements: Erythrocyte sedimentation rate (ESR). C reactive protein (CRP). Rheumatoid factor (RF) Anti-cyclic citrullinated peptide (Anti- CCP). glucocorticoid-induced tumour necrosis factor receptor related protein (GITR) (D) Musculoskeletal ultrasound assessment: Ultrasound examinations will be performed for patients and control groups using a Logiq e equipped with a broadband 8- to 13-MHz linear transducer Statistical analysis The collected data will be tabulated and analyzed using suitable statistical computer version.

Tracking Information